The basic goal is psychoeducational training

This article proposes a theoretical paradigm for the treatment of depression in the context of the biological and psychosocial aspects of bipolar disorders. The basic goal is psychoeducational training, which provides a framework for therapists, patients and their environment to understand depressive symptoms and stress vulnerability. Chronic unipolar depression and other forms of post-traumatic stress disorder (PTSD) require a combination of pharmacological or psychotherapeutic interventions and require the development of theoretical paradigms that integrate biological, psychosocial, and psychological aspects of depression.

At the heart of this model is the concept of psychobiological vulnerability, which is determined by the relationship between the biological and psychosocial aspects of individual vulnerability to stress.

The development of depression is symbolized by a negative downward loop, in which the interplay of symptoms, vulnerability and the stress factor puts the patient in a depressive state. Life events with unique stress-inducing values interact with vulnerability by triggering severe or chronic pain that impairs the resilience of individuals and leads to symptoms of depression. 

Moreover, the occurrence of recurrent depression significantly increases the risk of further relapse and influences both the psycho-biological vulnerability and the occurrence of stressors. The Biopsychosocial model emphasizes that biological, psychological, and therapeutic interventions must focus on symptom reduction and relapse prevention. It also provides a psychoeducational context in which the susceptibility to depressive symptoms in individuals can be treated both by the patient and in therapists. Finally, it provides a framework for developing a therapeutic approach to the prevention and treatment of depression and its symptoms.